Division of Medicinal Pharmacology
نویسنده
چکیده
I) 中枢神経系疾患の病態と発症機構に関する基礎研究 1) 心理的ストレス反応に関わる神経機構の薬理学的解析および神経機能修飾因子とその作用 分子機構の解析 2) 病態モデルにおける神経伝達物質等の内在性因子や天然薬物成分の脳内動態に関する研究 II) 複合薬物及びその成分の中枢作用に関する神経薬理学的研究 1) 脳血管性認知症病態モデル系における和漢薬および和漢薬成分の抗認知症作用と神経保護 作用の評価ならびに作用機序の解明 2) 神経保護薬をはじめ,新規リード化合物の開発をめざした伝統薬物・民族薬の薬理作用の 探索と作用機序の解析 3) 受容体遺伝子発現系を用いた受容体機能解析および薬物作用とその作用機序に関する電気 生理学的研究 III) 遺伝子発現を指標とした薬物作用の解明と和漢薬作用に関する研究 1) 慢性脳虚血等のストレスにより発現する脳内遺伝子のクローニングとその機能解析 2) 和漢薬を利用したうつ病態に関連する新規脳内遺伝子のクローニングと発現変化の作用 解析
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